1950
Eight days after the first World Championship event at Silverstone the racers were in action again at the Monaco Grand Prix. Alfa Romeo returned facing a bit more of a challenge than previously. Scudaria Ferrari entered their 125s driven by Gigi Villoresi, Alberto Ascari and Raymond Sommer. Alfa Romeo had three 158s for Giuseppe Farina, Juan-Manuel Fangio and Luigi Fagioli. A fourth car was entered by Peter Whitehead but a series of engine problems meant that he did not qualify. The rest of the field was made up of Talbot Lagos and Maseratis. Harry Schell entered a JAP-engined Cooper and there were a pair of Equipe Gordini Simca-Gordinis for drivers Maurice Trintignant and Robert Manzon.
The Monaco Grand Prix started with Fangio in pole position with a time of 1:50.2. Fangio's teammate, Giuseppe Farina, held the position next to him and in third was Maserati driver Gonzalez. Some unusual conditions occurred that Sunday in Monaco that would affect the race adversely. The wind in Monaco sprayed water from the harbor and made its way onto the track surface. The layer of water on the track made conditions slippery and caused a disaster. On the first lap Farina lost control of his car and was hit by Froilan Gonzalez in his Maserati. Fagioli swerved to a halt and Louis Rosier stopped his car before joining the wreck only to be pummeled into Ravioli's 158. A total of 9 cars were eliminated before the end of the first lap in Monaco. The drivers included in the crash were Farina, Fagioli, Rosier, Manzon, Graffenried, Trintignant, Harrison, Rol and Schell. The wreck left only 10 cars on the field and on the second lap Jose Froilan Gonzalez joined the retired cars as a result from a fire in his Maserati.
Fangio managed to escape the carnage at the end of the lap and Villoresi in his Ferrari stalled as he slowed down allowing Ascari to take second place. Villoresi was left in the dust of his competitors only to make a valiant attempt back to the lead. He charged his way back to second place only to have an axle problem on the sixty-third lap. The Argentine Fangio managed to hold the lead the entire race finishing at 3:13:18.7, a lap ahead of Ascari in his Ferrari. In third place was Louis Chiron in his Maserati finishing two laps behind.
Fangio made a comment after the Monaco Grand Prix, that he had been able to anticipate some of the danger when he noticed unusual movement in the crowd, his observations allowed him to avoid most of the danger.
| Pos | No | Driver | Team | Laps | Time/Retired |
| 1 | 34 | Juan Manuel Fangio | Alfa Romeo | .100 | 3:13'16 |
| 2 | 40 | Alberto Ascari | Ferrari | 99 | - 1 Lap |
| 3 | 48 | Louis Chiron | Maserati | 98 | - 2 Laps |
| 4 | 42 | Raymond Sommer | Ferrari | 97 | - 3 Laps |
| 5 | 50 | Prince Bira | Maserati | 95 | - 5 Laps |
| 6 | 26 | Bob Gerard | ERA | 94 | - 6 Laps |
| 7 | 6 | Johnny Claes | Lago-Talbot | 94 | - 6 Laps |
| DNF | 38 | Luigi Villoresi | Ferrari | 63 | Axle |
| DNF | 14 | Philippe Etancelin | Lago-Talbot | 38 | Oil leak |